abstract：:The process of thymopoiesis is tightly regulated by a series of selection events which ensure that only functional T-lymphocytes directed against foreign antigens are exported into the periphery. The adaptive immune response largely depends on the regulation of thymocyte development, and thymocytes which fail selectio...

journal_title：Immunobiology

authors： Hutcheson J,Perlman H

更新日期：2007-01-01 00:00:00

abstract：:Immunization using human papilloma virus (HPV)-L1 virus-like particles (VLPs) induces a robust and effective immune response, which has recently resulted in the implementation of the HPV-L1 VLP vaccination in health programs. However, during infection, HPV can escape immune surveillance leading to latency and disease....

journal_title：Immunobiology

authors： de Witte L,Zoughlami Y,Aengeneyndt B,David G,van Kooyk Y,Gissmann L,Geijtenbeek TB

更新日期：2007-01-01 00:00:00

abstract：:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...

journal_title：Immunobiology

authors： Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

更新日期：2007-01-01 00:00:00

abstract：:There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, ...

journal_title：Immunobiology

authors： Miletić T,Kovacević-Jovanović V,Vujić V,Stanojević S,Mitić K,Lazarević-Macanović M,Dimitrijević M

更新日期：2007-01-01 00:00:00

abstract：:The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were cloned and sequenced. Comparison with previously reported sequences showed that VH 14F7 belongs to the J558(VHI) gene family and that it is highly mutated. VH 4G9 belongs ...

journal_title：Immunobiology

authors： Rodríguez M,Roque-Navarro L,López-Requena A,Moreno E,Mateo de Acosta C,Pérez R,María Vázquez A

更新日期：2007-01-01 00:00:00

abstract：:C1q binds to immune complexes to elicit complement-dependent microbial killing and enhance phagocytosis. Besides this classical role, C1q also opsonizes apoptotic cells for clearance by phagocytes. C1q deficiency increases susceptibility to microbial infections and is also associated with elevated autoimmunity as char...

journal_title：Immunobiology

authors： Lu J,Wu X,Teh BK

更新日期：2007-01-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00

abstract：:Respiratory viral infections have been implicated in the origin of, protection from and exacerbation of allergy-related symptoms in a variety of ways. Viral infections are closely linked to infantile wheezing. Severe bronchiolitis in early infancy may predispose to chronic childhood asthma as well as allergic sensitiz...

journal_title：Immunobiology

authors： Xepapadaki P,Papadopoulos NG

更新日期：2007-01-01 00:00:00

abstract：:Cartilage-hair hypoplasia (CHH), or McKusick type metaphyseal chondrodysplasia, was first recognized as a distinct entity in the Old Order Amish in the USA, but was later identified in other groups, and found to be unusually frequent among Finns. CHH is highly pleiotropic with manifestations that include short stature...

journal_title：Immunobiology

authors： Muñoz-Robles J,Allende LM,Clemente J,Calleja S,Varela P,Gonzalez L,de Pablos P,Paz E,Morales P

更新日期：2006-01-01 00:00:00

abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...

journal_title：Immunobiology

authors： Endo Y,Takahashi M,Fujita T

更新日期：2006-01-01 00:00:00

abstract：:The interaction between the T cell receptor (TCR) and the peptide-MHC complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC) is the main event controlling the specificity of antigen recognition by T cells. It is thought that TCR/pMHC binding kinetics are critical for the selection of ...

journal_title：Immunobiology

authors： Carreño LJ,González PA,Kalergis AM

更新日期：2006-01-01 00:00:00

abstract：:CD163 and CD91 are scavenging receptors with highly increased expression during the differentiation of monocytes into the anti-inflammatory macrophage phenotype. In addition, CD91 is expressed in monocyte-derived dendritic cells (MoDCs), where the receptor is suggested to be important for internalization of CD91-targe...

journal_title：Immunobiology

authors： Maniecki MB,Møller HJ,Moestrup SK,Møller BK

更新日期：2006-01-01 00:00:00

abstract：:Macrophages are major effector cells of the innate immune system, and appropriate regulation of macrophage function requires the integration of multiple signalling inputs derived from the recognition of host factors (e.g. interferon-gamma/IFNgamma) and pathogen products (e.g. toll-like receptor/TLR agonists). The prof...

journal_title：Immunobiology

authors： Schroder K,Sweet MJ,Hume DA

更新日期：2006-01-01 00:00:00

abstract：:MHC class II molecules presenting MHC class II restricted antigens play an important role in the activation of CD4+ T cells, which are the central orchestrating cells of an immune response. This review focuses on the particular role of MHC class II molecules in tumour immunology. The MHC class II antigen presentation ...

journal_title：Immunobiology

authors： Chamuleau ME,Ossenkoppele GJ,van de Loosdrecht AA

更新日期：2006-01-01 00:00:00

abstract：:The leukocyte integrins CD11a/CD18 (LFA-1, alphaLbeta2) and CD49d (VLA-4, alpha4beta1, alpha4beta7) mediate leukocyte transendothelial migration during immune and inflammatory responses and provides co-stimulatory signals for the activation of T lymphocytes. Our previous studies demonstrate that the CD11a gene promote...

journal_title：Immunobiology

authors： Domínguez-Soto A,Relloso M,Vega MA,Corbí AL,Puig-Kröger A

更新日期：2005-01-01 00:00:00

abstract：:The phagocyte pattern recognition receptor Toll-like receptor 2 (TLR2) and the multi-receptor adaptor MyD88 contribute to the reduction of bacterial load in infections with intra- and extra-cellular Gram-positive bacteria. Their mechanism of antibacterial action is mostly unresolved but evident in vivo by an increased...

journal_title：Immunobiology

authors： Echchannaoui H,Bachmann P,Letiembre M,Espinosa M,Landmann R

更新日期：2005-01-01 00:00:00

abstract：:The putative expression of distinct terminally fucosylated glycoconjugates among murine lymphocyte subpopulations was sought using a Biomphalaria alexandrina-derived lectin (BaSI), of proven specificity to a fucosyllactose determinant, and the fucose-binding lectin from Lotus tetragonolobus seeds. Direct labeling of i...

journal_title：Immunobiology

authors： Mansour MH,Abdul-Salam F,Al-Shemary T

更新日期：2005-01-01 00:00:00

abstract：:Flavonoids are ubiquitous compounds present in plant extracts. They represent a major active component of the plant extract and are often known for their anti-inflammatory and anti-tumor effects. Previously, we demonstrated that Ligaria cuneifolia (R et P) Tiegh. (Loranthaceae) extracts inhibit proliferation of murine...

journal_title：Immunobiology

authors： Cerdá Zolezzi P,Fernández T,Aulicino P,Cavaliere V,Greczanik S,Caldas Lopes E,Wagner M,Ricco R,Gurni A,Hajos S,Alvarez E

更新日期：2005-01-01 00:00:00

abstract：:A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a descr...

journal_title：Immunobiology

authors： Asherson RA

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To investigate the close association between different antiphospholipid antibodies (aPL) caused by infection and their appearance together with a prolonged activated partial thromboplastin time (aPTT). METHODS:Sera from 122 children were evaluated in this study. Thirty-seven children with mild to medium prol...

journal_title：Immunobiology

authors： Frauenknecht K,Lackner K,von Landenberg P

更新日期：2005-01-01 00:00:00

abstract：:We have previously generated a murine anti-idiotype (Ab2) monoclonal antibody (mAb) to a murine Ab1 mAb, named P3, which selectively binds Neu-glycolyl (NeuGc)-sialic acid on several monosialo- and disialogangliosides, and also reacts with sulfatides and antigens expressed in human melanoma and breast tumors. This Ab2...

journal_title：Immunobiology

authors： Hernández AM,Rodríguez M,López-Requena A,Beausoleil I,Pérez R,Vázquez AM

更新日期：2005-01-01 00:00:00

abstract：:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B ...

journal_title：Immunobiology

authors： Cao W,He W

更新日期：2004-01-01 00:00:00

abstract：:Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important...

journal_title：Immunobiology

authors： Burke B

更新日期：2004-01-01 00:00:00

abstract：:Dendritic cells (DC) are efficient antigen presenting cells with the ability to activate naïve T cells. Murine DC represent a heterogeneous population that can be subdivided into distinct subsets, including the conventional DC (cDC) which are either CD4(-)CD8(-) (DN), CD4(+)CD8(-) (CD4+) or CD4(-)CD8(+) (CD8+) subsets...

journal_title：Immunobiology

authors： Proietto AI,O'Keeffe M,Gartlan K,Wright MD,Shortman K,Wu L,Lahoud MH

更新日期：2004-01-01 00:00:00

abstract：:Telomere erosion and residual replicative capacity can be used as markers of the replicative history of somatic cells. We have investigated telomere length, in vitro replicative capacity and rate of telomere erosion in T and B lymphocyte populations from patients with primary antibody deficiency requiring immunoglobul...

journal_title：Immunobiology

authors： Tucker VC,Rye AD,Harrison J,King L,Duddridge M,Browning MJ

更新日期：2004-01-01 00:00:00

abstract：:In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...

journal_title：Immunobiology

authors： Sugiura K,Nishikawa M,Ishiguro K,Tajima T,Inaba M,Torii R,Hatoya S,Wijewardana V,Kumagai D,Tamada H,Sawada T,Ikehara S,Inaba T

更新日期：2004-01-01 00:00:00

abstract：:Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human disease has used rodents deficient in C6, yet the molecular basis for the deficiencies has not been ascertained. Oligonucleotides derived from a 493 b...

journal_title：Immunobiology

authors： Bhole D,Stahl GL

更新日期：2004-01-01 00:00:00

abstract：:Th2 cells play a central role in type I allergies. However, the source of interleukin-4 which may lead to a Th1/Th2 imbalance is unknown. Valpha24+CD161+ Natural killer T (NKT) cells secrete high amounts of interleukin-4 and/or interferon-gamma and are assumed to participate in the initiation of Th1/Th2 immune respons...

journal_title：Immunobiology

authors： Prell C,Konstantopoulos N,Heinzelmann B,Frankenberger B,Reinhardt D,Schendel DJ,Krauss-Etschmann S

更新日期：2003-01-01 00:00:00

abstract：:Chemokines are important mediators of leukocyte recruitment and activation that play critical roles in the pathology of inflammatory diseases such as atherosclerosis, rheumatoid arthritis and asthma. The vaccinia virus (strain Lister) expresses a 35 kDa soluble protein ('35K') that binds and inactivates a wide range o...

journal_title：Immunobiology

authors： Bursill CA,Cai S,Channon KM,Greaves DR

更新日期：2003-01-01 00:00:00

abstract：:The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...

journal_title：Immunobiology

authors： Lejtenyi D,Osmond DG,Miller SC

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high (HIII) and low (LIII) antibody responsiveness. As previously shown, a lower pre-existing anti-MHV antibody level wa...

journal_title：Immunobiology

authors： Vassão RC,Consales CA,Sant'Anna OA,Pereira CA

更新日期：2003-01-01 00:00:00

abstract：:Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multi...

journal_title：Immunobiology

authors： Gottfried E,Faust S,Fritsche J,Kunz-Schughart LA,Andreesen R,Miyake K,Kreutz M

更新日期：2003-01-01 00:00:00

abstract：:Several, and not necessarily alternative, pathogenic mechanisms have been suggested to sustain the thrombophilic diathesis of the anti-phospholipid syndrome. Among them, interference of anti-phospholipid antibodies with cell acting in the coagulation cascade likely plays a major role. Anti-phospholipid antibodies have...

journal_title：Immunobiology

authors： Riboldi P,Gerosa M,Raschi E,Testoni C,Meroni PL

更新日期：2003-01-01 00:00:00

abstract：:This is the first application of flow cytometry for the detection of lamina propria plasma cells and their intracellular immunoglobulins in patients with inflammatory bowel disease compared to healthy controls. The study has been focused on the distribution of IgA, IgG, IgM and the four IgG subclasses. Plasma cells we...

journal_title：Immunobiology

authors： Dorn I,Schlenke P,Mascher B,Stange EF,Seyfarth M

更新日期：2002-12-01 00:00:00

abstract：:The innate immune system recognizes pathogen-associated molecular patterns (PAMP) to cope with evolving infections. Toll-like receptors (TLRs) play a pivotal role in recognition of PAMPs. In the course of infection not a single but rather a full panel of different microbial components interacts with distinct TLRs simu...

journal_title：Immunobiology

authors： Dalpke AH,Frey M,Morath S,Hartung T,Heeg K

更新日期：2002-10-01 00:00:00

abstract：:C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASPs). This review will initially summarize current information on the s...

journal_title：Immunobiology

authors： Arlaud GJ,Gaboriaud C,Garnier G,Circolo A,Thielens NM,Budayova-Spano M,Fontecilla-Camps JC,Volanakis JE

更新日期：2002-09-01 00:00:00

abstract：:Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (...

journal_title：Immunobiology

authors： Matsushita M,Fujita T

更新日期：2002-09-01 00:00:00

abstract：:Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactan...

journal_title：Immunobiology

authors： Clark H,Reid KB

更新日期：2002-09-01 00:00:00

abstract：:Beside the lung, thoracic lymph nodes are most affected during silicosis. The mechanisms leading to enlargement of the lymph nodes and partial activation of lymph node cells are still unclear. The present study demonstrates an increase in iNOS mRNA expression in the lung draining lymph nodes of rats at 1, 2, and 8 mon...

journal_title：Immunobiology

authors： Friedetzky A,Grau V,Wieckenberg M,Lewen A,Gemsa D,Garn H

更新日期：2002-07-01 00:00:00

abstract：:Reggie-1/flotillin-2 is a plasma membrane-associated cytoplasmic protein, which defines non-caveolar raft microdomains. Reggie-1/flotillin-2 is enriched in detergent insoluble (TX100) membrane fractions (DIG), co-localizes with activated GPI-linked proteins and the fyn-kinase in neurons and T cells, and thus apparentl...

journal_title：Immunobiology

authors： Solomon S,Masilamani M,Rajendran L,Bastmeyer M,Stuermer CA,Illges H

更新日期：2002-03-01 00:00:00